HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo
Abstract
Tumor hypoxia and high activity of hypoxia-inducible factor-1 (HIF-1) correlate with adverse disease outcomes, malignancy, resistance to therapy and metastasis. Nonetheless, recent studies indicate that under certain circumstances, HIF-1 stabilization may exert protective effects and even decrease tumor cell aggressiveness. This study aimed to characterize the potential anticancer effect of molidustat (BAY 85-3934), the prolyl hydroxylase (PHD)...
Paper Details
Title
HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo
Published Date
May 1, 2020
Journal
Volume
175
Pages
113922 - 113922
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