Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma
Abstract
Background Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV) and expression of viral T antigens or by ultraviolet-induced damage to the tumor genome from excessive sunlight exposure. An increasing number of deep sequencing studies of MCC have identified significant differences between the number and types of point mutations, copy number...
Paper Details
Title
Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma
Published Date
Mar 18, 2020
Journal
Volume
12
Issue
1
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