Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis

Volume: 39, Issue: 20, Pages: 4014 - 4027
Published: Mar 23, 2020
Abstract
Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activated by the nerve-derived neurotransmitter acetylcholine, we show that muscarinic receptors 1 and 3 (m1 and m3) are highly expressed in PCa clinical specimens compared with all other cancer types, and that amplification or gain of their...
Paper Details
Title
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis
Published Date
Mar 23, 2020
Journal
Volume
39
Issue
20
Pages
4014 - 4027
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