Effects of naringenin on the pharmacokinetics of tofacitinib in rats

Context Naringenin and tofacitinib are often used together for treatment of rheumatoid arthritis in Chinese clinics.Objective This experiment investigates the effect of naringenin on the pharmacokinetics of tofacitinib in rats.Materials and methods Twelve Sprague-Dawley rats were randomly divided into two groups (experimental group and control group). The experimental group was pre-treated with naringenin (150 mg/kg/day) for two weeks before...