Population Pharmacokinetics of IV Phenobarbital in Neonates After Congenital Heart Surgery

To develop a population pharmacokinetic model for IV phenobarbital in neonates following cardiac surgery and perform simulations to identify optimal dosing regimens.Retrospective single-center pharmacokinetic study.Cardiac ICU at Children's Hospital of Philadelphia.Consecutive neonates who received greater than or equal to one dose of IV phenobarbital and had greater than or equal to one phenobarbital concentration drawn per standard of care...