The missense variant p.(Gly482Arg) in HCN4 is responsible for fetal tachy-bradycardia syndrome

Fetal bradycardia mainly occurs as a symptom of fetal compromise or distress. However, fetal bradycardia can also occur owing to several other causes such as congenital displacement of atrial activation, acquired damage to the sinoatrial node, inherited arrhythmia syndromes, or secondary suppression of sinus node rate. Fetal bradycardia is observed in patients with inflammation and fibrosis of the sinus node owing to autoimmune antibodies (SSA...