Identification of peptides inhibiting the specific binding between AGEs and RAGE

Advanced glycation end products (AGEs), produced by non-enzymatic glycation between sugar (or its metabolites) and the amino residues on biomolecules, exert the inflammatory response via the stimulation of some pattern recognition receptors including RAGE. AGEs are known to increase in various age-related diseases, suggesting their involvement in chronic inflammation and tissue remodeling. Therefore, it is likely that the regulation of AGEs...