Effect of AGEs-Lf interaction on macrophage TNF-α expression

Advanced glycation end products (AGEs) are the potential inflammatory molecules produced by non-enzymatic glycation reaction between reducing sugar and amine residues on biomolecules, and have been suggested to be involved in various age-related diseases. AGEs stimulate the pattern recognition receptors (TLR4, TLR2, RAGE) on immune cells such as macrophages and vascular endothelial cells, and are involved in chronic inflammation and tissue...