Glycoconjugation: An approach to cancer therapeutics.

Published on Mar 24, 2020in World journal of clinical oncology
· DOI :10.5306/WJCO.V11.I3.110
Maria I Molejon1
Estimated H-index: 1
(National University of La Pampa),
Gisela Weiz1
Estimated H-index: 1
(National University of La Pampa)
+ 1 AuthorsMaria I. Vaccaro27
Estimated H-index: 27
(UBA: University of Buenos Aires)
Cancer constitutes the second leading cause of death globally and is considered to have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions can only be applied to a minority of patients at the time of diagnosis. Therefore, new therapeutic options are necessary for advanced stages of the disease. Glycosylation of antitumor agents, has been found to improve pharmacokinetic parameters, reduce side effects, and expand drug half-life in comparison with the parent compounds. In addition, glycosylation of therapeutic agents has been proven to be an effective strategy for their targeting tumor tissue, thereby reducing the doses of the glycodrugs administered to patients. This review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.
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