The effects of histidine-rich glycoprotein on neutrophil-like differentiated cell lines

Background: Excess immunothrombus formation induced by neutrophil adhesion on vascular wall, neutrophil extracellular traps (NETs) release and ROS production causes the multiple organ failure (MOF) in septic condition, leading to high mortality. Our previous study revealed that HRG treatment ameliorated the survival rate of septic mice due to suppressing the neutrophil adhesion, NETs release and immunothronbosis. These results suggested that HRG...