Internal medicine

Pathology

Chlamydia psittaci

Serology

Antibiotics

Biology

Microbiology

Antibody

Immunology

Lung

Psittacosis

Chlamydiaceae

Doxycycline

Pneumonia

Bronchoalveolar lavage

Chlamydophila pneumoniae

Moxifloxacin

Atypical pneumonia

Chlamydia

Medicine

BMC Pulmonary Medicine

Background Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci . Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. Case presentation This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone. Conclusions mNGS could be used to diagnose Chlamydia psittaci pneumonia.

The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases