Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study

Volume: 2, Issue: 1
Published: Jan 1, 2020
Abstract
Creutzfeldt–Jakob disease is a rare, fatal, neurodegenerative disease caused by the accumulation of abnormally folded prion proteins. The common polymorphism at codon 129 (methionine/valine) in the prion protein (PRNP) gene is the most important determinant of genetic susceptibility. Homozygotes of either allele have a higher risk of sporadic Creutzfeldt–Jakob disease. Various studies suggest that this polymorphism is also involved in other...
Paper Details
Title
Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study
Published Date
Jan 1, 2020
Volume
2
Issue
1
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