Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells

Volume: 175, Pages: 113908 - 113908
Published: May 1, 2020
Abstract
The ELAVL1 (or human antigen R - HuR) RNA binding protein stabilizes the mRNA, with an AU-rich element, of several genes such as growth factors (i.e. VEGF) and inflammatory cytokines (i.e. TNFα). We hereby carried out a virtual screening campaign in order to identify and test novel HuR-mRNA disruptors. Best-scored compounds were tested in an in-vitro model of diabetic retinopathy, namely human retinal endothelial cells (HRECs) challenged with...
Paper Details
Title
Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells
Published Date
May 1, 2020
Volume
175
Pages
113908 - 113908
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