Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation

Volume: 109, Issue: 6, Pages: 1924 - 1932
Published: Jun 1, 2020
Abstract
Polysorbates are stabilizers typically required in therapeutic protein formulations. On account of their chemical structure, polysorbates are prone to degradation, which can render a pharmaceutical product instable or incompliant. The purpose of this study was to investigate if the addition of butylhydroxytoluene (BHT) and butylhydroxyanisole (BHA) protects polysorbate 20 (PS20) and polysorbate 80 (PS80) against oxidative degradation. PS20 and...
Paper Details
Title
Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation
Published Date
Jun 1, 2020
Volume
109
Issue
6
Pages
1924 - 1932
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