Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization
Abstract
We describe our design, synthesis, and chemical study of a set of functional epidithiodiketopiperazines (ETPs) and evaluation of their activity against five human cancer cell lines. Our structure–activity relationship-guided substitution of ETP alkaloids offers versatile derivatization while maintaining potent anticancer activity, offering exciting opportunity for their use as there are no examples of complex and potently anticancer (nM) ETPs...
Paper Details
Title
Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization
Published Date
Mar 3, 2020
Journal
Volume
85
Issue
7
Pages
4648 - 4662
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