Receptor tyrosine kinase

Gene

ERBB3

Cyclin-dependent kinase 8

Growth factor receptor inhibitor

Notch signaling pathway

Receptor

Chemistry

Growth factor receptor

Epidermal growth factor

EGFR inhibitors

ErbB

Epidermal growth factor receptor

Tyrosine kinase

Cancer research

Biochemistry

Signal transduction

Regulator

Biology

Cell biology

Current Topics in Medicinal Chemistry

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors