MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors

Volume: 5, Issue: 6
Published: Mar 26, 2020
Abstract
Immune checkpoint inhibitor (ICI) therapy has shown a significant benefit in the treatment of a variety of cancer entities. However, immune-related adverse events (irAEs) occur frequently and can lead to ICI treatment termination. MicroRNA-146a (miR-146a) has regulatory functions in immune cells. We observed that mice lacking miR-146a developed markedly more severe irAEs compared with WT mice in several irAE target organs in 2 different murine...
Paper Details
Title
MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors
Published Date
Mar 26, 2020
Journal
Volume
5
Issue
6
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