Microrheology for Hi-C Data Reveals the Spectrum of the Dynamic 3D Genome Organization.
Abstract
The one-dimensional information of genomic DNA is hierarchically packed inside the eukaryotic cell nucleus and organized in a three-dimensional (3D) space. Genome-wide chromosome conformation capture (Hi-C) methods have uncovered the 3D genome organization and revealed multiscale chromatin domains of compartments and topologically associating domains (TADs). Moreover, single-nucleosome live-cell imaging experiments have revealed the dynamic...
Paper Details
Title
Microrheology for Hi-C Data Reveals the Spectrum of the Dynamic 3D Genome Organization.
Published Date
May 5, 2020
Journal
Volume
118
Issue
9
Pages
2220 - 2228
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