Abstract P4-10-14: Quantitative assessment of PD-L1 protein expression on macrophages and tumor cells as predictive markers of response to neoadjuvant durvalumab and chemotherapy in triple negative breast cancer (TNBC)

Background: In the IMpassion 130 trial, TNBC patients treated with Atezolizumab and nab-Paclitaxel that showed immune cell expression of PD-L1 showed better overall survival. The goal of this analysis was to assess association between quantitative PD-L1 expression, in various tissue compartments, and pathologic complete response (pCR: ypT0/N0) to neoadjuvant anti-PD-L1 therapy concurrent with nab-paclitaxel (100 mg/m2) x 12 followed by ddAC x 4...