Receptor

Estrogen receptor alpha

Autophagy

Nuclear receptor

Transcription factor

Biology

Estrogen-related receptor gamma

Gene

Cancer

Endocrinology

Apoptosis

Estrogen-related receptor alpha

Estrogen

Breast cancer

Cell biology

Estrogen receptor beta

Genetics

Biochemistry

Estrogen receptor

International Journal of Molecular Sciences

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases