Original paper

Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF‐1α‐independent VEGF expression and angiogenesis in hepatocellular carcinoma

Volume: 177, Issue: 14, Pages: 3240 - 3257
Published: Apr 12, 2020
Abstract
Background and Purpose As a typical hypervascular tumour, hepatocellular carcinoma (HCC) is predominantly grown through angiogenesis. Geniposide is a promising anti‐inflammatory compound found in Gardenia jasminoides , but its effects on the progression of HCC remain untested. Experimental Approach The anti‐HCC effects of geniposide was investigated in cellular models and orthotopic HCC mice. Transcriptional regulation of the VEGF promoter was...
Paper Details
Title
Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF‐1α‐independent VEGF expression and angiogenesis in hepatocellular carcinoma
Published Date
Apr 12, 2020
Volume
177
Issue
14
Pages
3240 - 3257
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