Pathology

Middle East respiratory syndrome coronavirus

Disease

Evasion (ethics)

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Pandemic

Virology

Pathogen

Immunology

Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Medicine

Immune system

Asian Pacific Journal of Allergy and Immunology

As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS.The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future.This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies.This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.

Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic