Effects of tricalcium silicate/sodium alginate/calcium sulfate hemihydrate composite cements on osteogenic performances in vitro and in vivo

In this study, ternary organic–inorganic composite bone cements of tricalcium silicate/sodium alginate/calcium sulfate hemihydrate (C3S/SA/CS) were successfully fabricated for in vitro and in vivo osteogenesis study, mainly including proliferation, attachment and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, and bone regeneration in critical-sized rabbit femoral condyle defect model. Bone marrow mesenchymal stem cells...