Original paper

Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein

Volume: 27, Issue: 3, Pages: 274 - 280
Published: Mar 1, 2020
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide hormone. The PACAP receptor PAC1R, which belongs to the class B G-protein-coupled receptors (GPCRs), is a drug target for mental disorders and dry eye syndrome. Here, we present a cryo-EM structure of human PAC1R bound to PACAP and an engineered Gs heterotrimer. The structure revealed that transmembrane helix TM1 plays an essential role in PACAP recognition....
Paper Details
Title
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein
Published Date
Mar 1, 2020
Volume
27
Issue
3
Pages
274 - 280
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