Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Abstract
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S...
Paper Details
Title
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Published Date
Apr 1, 2020
Journal
Volume
181
Issue
2
Pages
281 - 292.e6
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