Avapritinib: First Approval
Abstract
Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal tumours (GIST), solid tumours and systemic mastocytosis. Avapritinib is approved in the USA for PDGFRA exon 18 (including D842V) mutant GIST and is undergoing regulatory assessment in the USA...
Paper Details
Title
Avapritinib: First Approval
Published Date
Feb 25, 2020
Journal
Volume
80
Issue
4
Pages
433 - 439
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