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doi.org/10.1016/j.ebiom.2020.102689

Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis

..., Guang-Biao Zhou
37
EBioMedicine11.10
Volume: 53, Pages: 102689 - 102689
Published: Mar 1, 2020
Abstract
BackgroundHow the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be systematically identified.MethodsA total of 696 UPGs (including E1, E2, E3, and deubiquitinases) were silenced by small interfering RNA (siRNA) library in NSCLC cells, the candidates were verified, and...
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Paper Details
Title
Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis
DOI
doi.org/10.1016/j.ebiom.2020.102689
Published Date
Mar 1, 2020
Journal
EBioMedicine
Volume
53
Pages
102689 - 102689
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