Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
Abstract
Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has both genetic and environmental risk factors, resulting in impaired glucose homeostasis. Genome-wide association studies (GWAS) have identified over 400 genetic signals that are associated with altered risk of T2DM. Human physiology and epigenomic data support a central role for the pancreatic islet in the pathogenesis of T2DM. This Review focuses on the...
Paper Details
Title
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
Published Date
Feb 25, 2020
Journal
Volume
16
Issue
4
Pages
202 - 212
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