Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels

Background and Purpose Cardiovascular complications are the major cause of mortality in diabetic patients. However, the molecular mechanisms underlying diabetes‐associated arrhythmias are unclear. We hypothesized that high glucose could adversely affect Na v 1.5, the major cardiac sodium channel isoform of the heart, at least partially via oxidative stress. We further hypothesized that cannabidiol (CBD), one of the main constituents of Cannabis...