Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

Importance

The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain.

Objective

To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations.

Design, Setting, and Participants

Observational study of UK Biobank participants enrolled from 2006 to 2010. A case-control sample of 15 947...