Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
Abstract
Some effector CD4+ T cell subsets display cytotoxic activity, thus breaking the functional dichotomy of CD4+ helper and CD8+ cytotoxic T lymphocytes. However, molecular mechanisms regulating CD4+ cytotoxic T lymphocyte (CD4+ CTL) differentiation are poorly understood. Here we show that levels of histone deacetylases 1 and 2 (HDAC1-HDAC2) are key determinants of CD4+ CTL differentiation. Deletions of both Hdac1 and 1 Hdac2 alleles...
Paper Details
Title
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
Published Date
Feb 27, 2020
Journal
Volume
5
Issue
4
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