Haematopoiesis

Biochemistry

Cell

Biology

Stem cell

Metabolism

Cell biology

Glycolysis

In vivo

Mitochondrion

Hematopoietic stem cell

Genetics

Cell stem cell

The quiescence and potency of hematopoietic stem cells (HSCs) are thought to be maintained by glycolysis. By exploiting mitochondrial heterogeneity, Liang, Arif, et al. uncover that activated, but not quiescent, HSCs use glycolysis for energy. Quiescence is maintained by an abundance of lysosomes whose repression enhances HSC potency by over 90-fold.

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency