Anti-tumor effect of PEG-coated PLGA nanoparticles of febuxostat on A549 non-small cell lung cancer cells

In the present study, febuxostat (FBX)-loaded PEG-coated PLGA nanoparticles (FBX–PLGA–PEG) were developed and its anticancer activity on lung cancer cells was evaluated. FBX–PLGA–PEG were prepared by nanoprecipitation technique and characterized for particle size, size distribution, entrapment efficiency, and in vitro drug release study. The optimized formulations were used to evaluate cell viability, apoptosis, cell cycle, and caspase activity...