Encapsulation and Storage of Therapeutic Fibrin-Homing Peptides using Conducting Polymer Nanoparticles for Programmed Release by Electrical Stimulation

Cys-Arg-Glu-Lys-Ala (CREKA) is an important fibrin-homing pentapeptide that has been extensively demonstrated for diagnoses and therapies (e.g., image diagnosis of tumors and to inhibit tumor cell migration and invasion). Although CREKA-loaded nanoparticles (NPs) have received major interest as efficient biomedical systems for cancer diagnosis and treatment, almost no control on the peptide release has been achieved yet. Herein, we report the...