Organic chemistry

Glycoside

Combinatorial chemistry

Stereochemistry

Chemistry

1,2,4-Triazole

Triazole

Antimicrobial

Molecules

Bacterial resistance remains a significant threat and a leading cause of death worldwide, despite massive attempts to control infections. In an effort to develop biologically active antibacterial and antifungal agents, six novel aryl-substituted-1,2,3-triazoles linked to carbohydrate units were synthesized through the Cu(I)-catalyzed azide-alkyne cycloaddition CuAAC of substituted-arylazides with a selection of alkyne-functionalized sugars. The chemical structures of the new derivatives were verified using different spectroscopic techniques. The novel clicked 1,2,3-triazoles were evaluated for in vitro antibacterial activity against Gram-positive

Design, Synthesis, and Antimicrobial Activities of 1,2,3-Triazole Glycoside Clickamers