Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
Abstract
Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the intracellular microenvironment, which is under the constitutive control of glutathione peroxidase 4 (GPX4). Ferrous iron (Fe2+) accumulation and lipid peroxidation are critical events in the induction of ferroptosis, which is inhibited by iron chelators and lipophilic antioxidants. Ferroptosis terminates in mitochondrial dysfunction and toxic lipid...
Paper Details
Title
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
Published Date
Jul 1, 2020
Journal
Volume
483
Pages
127 - 136
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