On the prevention of kidney uptake of radiolabeled DARPins
Abstract
Background Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPins labeled with residualizing labels is a limitation for targeted radionuclide therapy. A better understanding of the mechanisms behind the kidney uptake of DARPins could aid the development of strategies to...
Paper Details
Title
On the prevention of kidney uptake of radiolabeled DARPins
Published Date
Feb 4, 2020
Journal
Volume
10
Issue
1
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