Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke
Abstract
Background and Purpose— Microglia/macrophages (Mi/MΦ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (proinflammatory or anti-inflammatory; deleterious or salutary). Identification of the molecular mechanisms that dictate the functional status of Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized that activation of TAK1 (transforming growth factor...
Paper Details
Title
Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke
Published Date
Feb 12, 2020
Journal
Volume
51
Issue
3
Pages
975 - 985
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