Aspermeroterpenes A–C: Three Meroterpenoids from the Marine-Derived Fungus Aspergillus terreus GZU-31-1

Aspermeroterpene A (1) with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B (2) and C (3), were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for 1–3 is proposed. Aspermeroterpenes A–C (1–3) showed significant...