Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Abstract
Activated by interaction Cytokines trigger immune responses when they bind to their cognate receptors. Class I cytokine receptors rely on the associated Janus kinase 2 (JAK2) to initiate signal transduction. There has been debate over whether activation involves ligand-induced dimerization of these receptors or ligand-induced conformational change of preformed dimers. Wilmes et al. imaged cytokine receptors in the plasma membranes of live human...
Paper Details
Title
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Published Date
Feb 7, 2020
Journal
Volume
367
Issue
6478
Pages
643 - 652
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Notes
History