Chemogenomics analysis of drug targets for the treatment of acute promyelocytic leukemia
Abstract
The main challenges in treating acute promyelocytic leukemia (APL) are currently early mortality, relapse, refractory disease after induction therapy, and drug resistance to ATRA and ATO. In this study, a computational chemogenomics approach was used to identify new molecular targets and drugs for APL treatment. The transcriptional profiles induced by APL were compared with those induced by genetic or chemical perturbations. The genes that can...
Paper Details
Title
Chemogenomics analysis of drug targets for the treatment of acute promyelocytic leukemia
Published Date
Feb 4, 2020
Journal
Volume
99
Issue
4
Pages
753 - 763
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