Fibroblast

Population

Cell culture

Biology

Molecular biology

Immunology

T cell

Dermal fibroblast

Genetics

Medicine

Immune system

Environmental health

Journal of Allergy and Clinical Immunology

Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue biopsy studies that have advanced the mechanistic understanding of AD, single cell–based molecular alterations are largely unknown.

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis