Slc7a5 Alters the Functional Interaction between Kv1.2 and Kvβ

The voltage-gated potassium channel Kv1.2 plays a pivotal role in the nervous system, where it regulates membrane excitability and action potential propagation. Mutations and dysfunction of Kv1.2 result in neurodevelopmental delay and seizures. The established accessory proteins for Kv1.2 (and other Kv1 channels) are the Kvβ subunits, which promote cell surface expression and N-type inactivation of the channel. A ‘ball and chain’ peptide in the...