Bevacizumab has bidirectional regulatory effects on the secretion of basic fibroblast growth factor in glioma cells
Abstract
Previous studies suggest that upregulated basic fibroblast growth factor (bFGF) plays a key role in the resistance to anti-vascular endothelial growth factor (VEGF) therapy in glioma. This study reported that anti-VEGF treatment regulated bFGF secretion in a double-edged manner. That is, moderate VEGF neutralization reduced bFGF production, whereas VEGF overblocking enhanced bFGF secretion in glioma cells. Our data provide a new perspective on...
Paper Details
Title
Bevacizumab has bidirectional regulatory effects on the secretion of basic fibroblast growth factor in glioma cells
Published Date
May 1, 2020
Journal
Volume
129
Pages
155022 - 155022
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