Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness

Volume: 117, Issue: 7, Pages: 3528 - 3534
Published: Feb 3, 2020
Abstract
In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular processes, which has complicated attempts to deconvolve the extent to which synonymous codon usage can promote or frustrate proper protein folding...
Paper Details
Title
Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness
Published Date
Feb 3, 2020
Volume
117
Issue
7
Pages
3528 - 3534
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