Integrating natriuretic peptides and diastolic dysfunction to predict adverse events in high-risk asymptomatic subjects

Published on Aug 9, 2021in European Journal of Preventive Cardiology5.864
· DOI :10.1177/2047487319899618
Mauro Gori11
Estimated H-index: 11
,
Carolyn S.P. Lam78
Estimated H-index: 78
(NUS: National University of Singapore)
+ 13 AuthorsMichele Senni51
Estimated H-index: 51
Sources
Abstract
BackgroundNatriuretic peptides and diastolic dysfunction have prognostic value in asymptomatic subjects at risk for heart failure. Their integration might further refine the risk stratification pro...
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Abstract Background Soluble suppression of tumorigenesis-2 (sST2) is a biomarker related to inflammation and fibrosis. Objectives This study assessed the independent prognostic value of sST2 in chronic heart failure (HF). Methods Individual patient data from studies that assessed sST2 for risk prediction in chronic HF, together with N-terminal pro−B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT), were retrieved. Results A total of 4,268 patients were evaluated (med...
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Abstract Background Circulating B-type natriuretic peptide (BNP) concentrations strongly predict mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence BNP levels, suggesting that BNP might have similar prognostic value in patients without HF. Objectives The aim of this study was to compare the prognostic value of BNP between patients with and those without HF. Methods Using the Vanderbilt University Medical Center electronic health record, 30,487 patients...
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BackgroundThe Seattle heart failure model or the cardiac and comorbid conditions (3C-HF) scores may help define patient risk in heart failure. Direct comparisons between them or versus N-terminal fraction of pro-B-type natriuretic peptide (NT-proBNP) have never been performed.MethodsData from consecutive patients with stable systolic heart failure and 3C-HF data were examined. A subgroup of patients had the Seattle heart failure model data available. The endpoints were one year all-cause or card...
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Abstract Background Despite the burden of pre-clinical heart failure (HF) among diabetes mellitus (DM) patients, routine screening echocardiography is not currently recommended. We prospectively assessed risk prediction for HF/death of a screening strategy combining clinical data, electrocardiogram, NTproBNP, and echocardiogram, aiming to identify DM patients more suitable for selective echocardiography. Methods Among 4047 screened subjects aged≥55/≤80years, the DAVID-Berg Study prospectively en...
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Background:Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of ...
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Article, see p 1494 Heart failure (HF) prevalence continues to rise, and projections show that in the next 2 decades, ≈45% more HF cases will occur, with a mortality rate remaining as high as 50% within 5 years of diagnosis and high healthcare costs. Hence, there is an unmet need to apply successful preventive programs and reduce HF incidence. Also, according to current guidelines, an effective HF preventive program requires adequately targeting the preclinical stages of the disease, including r...
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Abstract Background High-output heart failure (HF) is an unusual cause of cardiac failure that has not been well-characterized. Objectives This study sought to characterize the etiologies, pathophysiology, clinical and hemodynamic characteristics, and outcomes of high-output HF in the modern era. Methods We performed a retrospective analysis of all consecutive patients referred to the Mayo Clinic catheterization laboratory for hemodynamic assessment between 2000 and 2014. Subjects with definite ...
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Background Preventing the evolution of subclinical cardiac disease into overt heart failure is of paramount importance. Imaging techniques, particularly transthoracic echocardiography (TTE), are well suited to identify abnormalities in cardiac structure and function that precede the development of heart failure. Methods This meta-analysis provides a comprehensive evaluation of 32 studies from 11 individual cohorts, which assessed cardiac indices from TTE (63%), cardiovascular magnetic resonance ...
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Abstract Background Diastolic dysfunction (DD) might help to risk stratify patients with heart failure (HF) with reduced ejection fraction (HFrEF). Nonetheless, HF guidelines/risk scores don't consider DD. We aimed to show the independent prognostic value of DD for nonfatal HF/death in patients with HFrEF on top of natriuretic peptides (NP). Methods We analyzed 1155 baseline echocardiograms of the MADIT-CRT study (LVEF≤30%, QRS ≥ 130 ms, NYHA class I/II), classifying DD according to 2016 ASE/EAC...
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