Review paper

Divergent mutational processes distinguish hypoxic and normoxic tumours

Volume: 11, Issue: 1
Published: Feb 5, 2020
Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome...
Paper Details
Title
Divergent mutational processes distinguish hypoxic and normoxic tumours
Published Date
Feb 5, 2020
Volume
11
Issue
1
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