Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy
Abstract
Atherosclerosis-related cardiovascular disease is still the predominant cause of death worldwide. Araloside C (AsC), a natural saponin, exerts extensive anti-inflammatory properties. In this study, we explored the protective effects and mechanism of AsC on macrophage polarization in atherosclerosis in vivo and in vitro. Using a high-fat diet (HFD)-fed ApoE-/- mouse model and RAW264.7 macrophages exposed to ox-LDL, AsC was evaluated for its...
Paper Details
Title
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy
Published Date
Jan 27, 2020
Journal
Volume
12
Issue
2
Pages
1704 - 1724
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