Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation
Abstract
Rhythms in the pseudo-steady state (PSS) levels of reactive species (RS), particularly superoxide and hydroxyl radicals, exist in cancer cells. The RS rhythm characteristics, particularly frequency and amplitude, are entrained (reset) by the anticancer compounds/drugs. In this work, we show for the first time that the phase of the RS rhythm at which the drug is added is significantly important in determining the cytotoxicity of anticancer...
Paper Details
Title
Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation
Published Date
Jan 31, 2020
Journal
Volume
10
Issue
1
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