Structure and Roles of V-type ATPases

Structures of the intact yeast V-ATPase have revealed the rotary mechanism of the complex and the dynamics associated with enzyme activity. The structures of the isolated V1 and VO regions have shown conformational changes associated with reversible disassembly and silencing of activity. An atomic model of the VO region has revealed the proton-translocation pathway. Biochemical studies have shown the isoform-specific characteristics of yeast...